486 research outputs found
You Saw THAT?: Social Networking Sites, Self-Presentation, and Impression Formation in the Hiring Process
Facebook, Twitter, LinkedIn – individuals have more opportunities than ever before to present themselves in public using social networking sites (SNSs). However, individuals tend to live segmented lives and often develop different self-presentations depending on the audience. The combination of opportunities to present publicly and presenting different self-presentations can have unforeseen impacts for job candidates. From employers’ perspectives, access to this public information represents a new source of information about job candidates. This paper studies how self-presentations of candidates in SNSs affect impressions formed of candidates by individuals faced with a hiring decision. Utilizing the self-presentation and impression management literature, a model is developed and tested utilizing data from an online survey-based experiment. Findings of the study suggest information from self-presentations is seen as valuable, yet can create ambiguity for decision makers. Implications for theory and hiring organizations assessing the influence of SNSs on hiring are discussed
SHOULD I STAY OR SHOULD I GO: THE ROLE OF REFERRALS ON ONLINE COMMUNITY MEMBER TURNOVER AND TENURE
Communities are often faced with challenges associated with attracting and maintaining a membership base, which affects their ability to develop a pool of resources and ultimately impacts their sustainability. A potential resolution to this challenge lies in the members of the community referring non-members to the community – member referrals. While community joining has been acknowledged as important stage in the life cycle of community members; however, the way in which a member becomes aware of a community and its resulting influence on their engagement with the community has not been examined. This research-in-progress paper outlines the examination of the role of referrals on member turnover and tenure. Drawing upon theories of referrals from organizational behavior and marketing, the paper theorizes that referrals have the potential to facilitate the awareness of, and interest in, a community, which ultimately influences new members to return to, and stay, in a community
I Didn\u27t Know You Could See That: The Effect of Social Networking Environment Characteristics on Publicness and Self-Disclosure
Web 2.0 technologies have changed the way users interact with the Internet. Users play a growing role in the generation of content, and while doing so disclose a piece of themselves. We seek to provide a theoretical link between the boundary characteristics of a social networking website and self-disclosure. Utilizing Communication Privacy Management Theory, we focus on two forms of boundaries: mode of entry boundary and ingroup/outgroup boundary. We propose that these boundaries play a role in the implicit boundary coordination and negotiation between the users of the environment and the website. This negotiation influences users’ perceived publicness of the environment, which influences their self-disclosure behaviors due to their risk avoidance. It is believed that by recognizing the public aspect of participation in online social networks, we can provide suggestions on how its perception can be managed to encourage, or discourage, contributions and disclosures of information by users
SarS, a SarA Homolog Repressible by agr, Is an Activator of Protein A Synthesis in Staphylococcus aureus
The expression of protein A (spa) is repressed by global regulatory loci sarA and agr. Although SarA may directly bind to the spa promoter to downregulate spa expression, the mechanism by which agr represses spa expression is not clearly understood. In searching for SarA homologs in the partially released genome, we found a SarA homolog, encoding a 250-amino-acid protein designated SarS, upstream of the spa gene. The expression of sarS was almost undetectable in parental strain RN6390 but was highly expressed in agr and sarA mutants, strains normally expressing high level of protein A. Interestingly, protein A expression was decreased in a sarS mutant as detected in an immunoblot but returned to near-parental levels in a complemented sarS mutant. Transcriptional fusion studies with a 158- and a 491-bp spa promoter fragment linked to the xylE reporter gene disclosed that the transcription of the spa promoter was also downregulated in the sarS mutant compared with the parental strain. Interestingly, the enhancement in spa expression in an agr mutant returned to a near-parental level in the agr sarS double mutant but not in the sarA sarS double mutant. Correlating with this divergent finding is the observation that enhanced sarS expression in an agr mutant was repressed by the sarA locus supplied in trans but not in a sarA mutant expressing RNAIII from a plasmid. Gel shift studies also revealed the specific binding of SarS to the 158-bp spa promoter. Taken together, these data indicated that the agr locus probably mediates spa repression by suppressing the transcription of sarS, an activator of spa expression. However, the pathway by which the sarA locus downregulates spa expression is sarS independent
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Comparative safety of anesthetic type for hip fracture surgery in adults: retrospective cohort study
Objective: To evaluate the effect of anesthesia type on the risk of in-hospital mortality among adults undergoing hip fracture surgery in the United States. Design: Retrospective cohort study. Setting: Premier research database, United States. Participants: 73 284 adults undergoing hip fracture surgery on hospital day 2 or greater between 2007 and 2011. Of those, 61 554 (84.0%) received general anesthesia, 6939 (9.5%) regional anesthesia, and 4791 (6.5%) combined general and regional anesthesia. Main outcome measure In-hospital all cause mortality. Results: In-hospital deaths occurred in 1362 (2.2%) patients receiving general anesthesia, 144 (2.1%) receiving regional anesthesia, and 115 (2.4%) receiving combined anesthesia. In the multivariable adjusted analysis, when compared with general anesthesia the mortality risk did not differ significantly between regional anesthesia (risk ratio 0.93, 95% confidence interval 0.78 to 1.11) or combined anesthesia (1.00, 0.82 to 1.22). A mixed effects analysis accounting for differences between hospitals produced similar results: compared with general anesthesia the risk from regional anesthesia was 0.91 (0.75 to 1.10) and from combined anesthesia was 0.98 (0.79 to 1.21). Findings were also consistent in subgroup analyses. Conclusions: In this large nationwide sample of hospital admissions, mortality risk did not differ significantly by anesthesia type among patients undergoing hip fracture surgery. Our results suggest that if the previously posited beneficial effect of regional anesthesia on short term mortality exists, it is likely to be more modest than previously reported
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Genetic contribution to postpartum haemorrhage in Swedish population: cohort study of 466 686 births
Objective: To investigate the familial clustering of postpartum haemorrhage in the Swedish population, and to quantify the relative contributions of genetic and environmental effects. Design: Register based cohort study. Setting: Swedish population (multi-generation and medical birth registers). Main outcome measure Postpartum haemorrhage, defined as >1000 mL estimated blood loss. Participants: The first two live births to individuals in Sweden in 1997-2009 contributed to clusters representing intact couples (n=366 350 births), mothers with separate partners (n=53 292), fathers with separate partners (n=47 054), sister pairs (n=97 228), brother pairs (n=91 168), and mixed sibling pairs (n=177 944). Methods: Familial clustering was quantified through cluster specific tetrachoric correlation coefficients, and the influence of potential sharing of known risk factors was evaluated with alternating logistic regression. Relative contributions of genetic and environmental effects to the variation in liability for postpartum haemorrhage were quantified with generalised linear mixed models. Results: The overall prevalence of postpartum haemorrhage after vaginal deliveries in our sample was 4.6%. Among vaginal deliveries, 18% (95% confidence interval 9% to 26%) of the variation in postpartum haemorrhage liability was attributed to maternal genetic factors, 10% (1% to 19%) to unique maternal environment, and 11% (0% to 26%) to fetal genetic effects. Adjustment for known risk factors only partially explained estimates of familial clustering, suggesting that the observed shared genetic and environmental effects operate in part through pathways independent of known risk factors. There were similar patterns of familial clustering for both of the main subtypes examined (atony and retained placenta), though strongest for haemorrhage after retained placenta. Conclusions: There is a maternal genetic predisposition to postpartum haemorrhage, but more than half of the total variation in liability is attributable to factors that are not shared in families
Herpes simplex virus and rates of cognitive decline or whole brain atrophy in the Dominantly Inherited Alzheimer Network
OBJECTIVE: To investigate whether herpes simplex virus type 1 (HSV-1) infection was associated with rates of cognitive decline or whole brain atrophy among individuals from the Dominantly Inherited Alzheimer Network (DIAN).
METHODS: Among two subsets of the DIAN cohort (age range 19.6-66.6 years; median follow-up 3.0 years) we examined (i) rate of cognitive decline (N = 164) using change in mini-mental state examination (MMSE) score, (ii) rate of whole brain atrophy (N = 149), derived from serial MR imaging, calculated using the boundary shift integral (BSI) method. HSV-1 antibodies were assayed in baseline sera collected from 2009-2015. Linear mixed-effects models were used to compare outcomes by HSV-1 seropositivity and high HSV-1 IgG titres/IgM status.
RESULTS: There was no association between baseline HSV-1 seropositivity and rates of cognitive decline or whole brain atrophy. Having high HSV-1 IgG titres/IgM was associated with a slightly greater decline in MMSE points per year (difference in slope - 0.365, 95% CI: -0.958 to -0.072), but not with rate of whole brain atrophy. Symptomatic mutation carriers declined fastest on both MMSE and BSI measures, however, this was not influenced by HSV-1. Among asymptomatic mutation carriers, rates of decline on MMSE and BSI were slightly greater among those who were HSV-1 seronegative. Among mutation-negative individuals, no differences were seen by HSV-1. Stratifying by APOE4 status yielded inconsistent results.
INTERPRETATION: We found no evidence for a major role of HSV-1, measured by serum antibodies, in cognitive decline or whole brain atrophy among individuals at high risk of early-onset AD
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